Drug Treatment for Alzheimer’s Disease is Lacking

Drugs developed to treat Alzheimer’s disease produce only fleeting memory improvements and do not slow the overall course of the disease. Acetylcholinesterase inhibitors such as Aricept, Razadyne, and Exelon and NMDA receptor inhibitors such as Namenda have very limited value. There is a new experimental drug called J147 that at least in mice enhances memory in both normal and ALzheimer’s mice and also oprotects the brain from loss of synaptic connections. It is many years from reaching the market, and that is if it reaches it at all. There are other approaches that could be used clinically today that are underappreciated. New research shows that Alzheimer’s disease is akin to an electrical brown out. Neurons simply cannot use glucose to make enough energy and they gradually die. It is possible to provide an alternate form of energy using saturated fats that are metabolized to ketone bodies. These ketone bodies provide an alternate source of ATP production. This along with niacinamide, choline, B12, and curcumin may help delay the progression or even improve the status of Alzheimer’s disease.

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